Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential

Protein methylation is a key post-translational modification whose effects on gene expression have been intensively studied over the last two decades. Recently, renewed interest in non-histone protein has gained momentum for its role regulating important cellular processes and activity of many proteins, including transcription factors, enzymes, structural complexes. The extensive dynamic that plays within cell also highlights potential bioengineering applications. Indeed, while synthetic histone extensively used to engineer expression, engineering not fully explored yet. Here, we report latest findings, highlighting how fundamental certain functions implicated disease, review recent efforts methylation.